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I had a similar issue with a MS 5050 wireless keyboard and mouse on my brand new MacBook Pro. Mouse would work fine, then jump all over the place. Keyboard would work, then miss random keystrokes, and then work again. Drove me crazy. Put in new batteries, no change. I took the keyboard and mouse home and both worked flawlessly on my old MacBook Air.

Clearly not the hardware. Wireless interference at the office? I tried various desks around the building. No change, erratic behaviour continued. Weeks later I happened to read about Thunderbolt-3 / USB-C port adapters causing noise problems with HDMI monitors. The new MacBooks (annoyingly) have no standard USB ports, so I was forced to used a port adaptor for USB and the HDMI monitor. The little MS wireless receiver dongle had been inserted in the adapter right next to the HDMI monitor cable.

Found a short USB extension cable, used it to position the wireless receiver 2 feet away from the adapter. Mouse and keyboard both work perfectly now. A few days ago I was temporarily using a different monitor with a very high quality HDMI cable. Curious, I forgo the extension and inserted the wireless receiver directly into the port converter again.

Keyboard and mouse worked fine. So maybe it isn't the port converter but the HDMI cable generating the interference? But I'm taking no chances.

The USB extension cable is back in its place as I type this, without frustration, on my 5050 wireless keyboard.